invivoPKfit: Fits Toxicokinetic Models to In Vivo PK Data Sets
Takes in vivo toxicokinetic concentration-time data and fits parameters of 1-compartment and 2-compartment models for each chemical. These methods are described in detail in "Informatics for Toxicokinetics" (2025).
| Version: | 2.0.2 |
| Depends: | R (≥ 4.1.0) |
| Imports: | cli, dplyr, ggplot2, httk, MASS, Matrix, mirai, numDeriv, optimx, PK, pracma, purrr, rlang, stats, scales, tibble, tidyr |
| Suggests: | cowplot, knitr, RColorBrewer, rmarkdown, stringr, testthat (≥ 3.0.0), glue, tidyverse |
| Published: | 2025-08-26 |
| Author: | John Wambaugh 
[aut, cre],
Caroline Ring
[aut],
Gilberto Padilla Mercado
[aut],
Chris Cook [aut] |
| Maintainer: | John Wambaugh <wambaugh.john at epa.gov> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| CRAN checks: | invivoPKfit results |
Documentation:
| Reference manual: | invivoPKfit.html , invivoPKfit.pdf |
| Vignettes: |
invivoPKfit User Guide (source, R code) Wambaugh et al. (2018): Estimating TK Parameters from In Vivo Data (source, R code) Informatics for toxicokinetics (source, R code) |
Downloads:
| Package source: | invivoPKfit_2.0.2.tar.gz |
| Windows binaries: | r-devel: invivoPKfit_2.0.1.zip, r-release: invivoPKfit_2.0.1.zip, r-oldrel: invivoPKfit_2.0.1.zip |
| macOS binaries: | r-release (arm64): invivoPKfit_2.0.2.tgz, r-oldrel (arm64): invivoPKfit_2.0.2.tgz, r-release (x86_64): invivoPKfit_2.0.1.tgz, r-oldrel (x86_64): invivoPKfit_2.0.1.tgz |
| Old sources: | invivoPKfit archive |
Linking:
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