Ahmad, Omar B, Cynthia Boschi Pinto, Alan D Lopez, Christopher JL
Murray, Rafael Lozano, and Mie Inoue. 2001. “Age Standardization
of Rates: A New WHO Standard.” GPE Discussion Paper Series: No.
31. Geneva: World Health Organization.
Askari, Maryam, and Seyedeh Mahdieh Namayandeh. 2020.
“The
Difference Between the Population Attributable Risk (PAR) and the
Potentioal Impact Fraction (PIF).” Iranian Journal of Public
Health 49 (10): 2018–19.
https://doi.org/10.18502/ijph.v49i10.4713.
Attema, Arthur E., Werner B. F. Brouwer, and Karl Claxton. 2018.
“Discounting in Economic Evaluations.”
PharmacoEconomics 36 (7): 745–58.
https://doi.org/10.1007/s40273-018-0672-z.
Boardman, Anthony E., David H. Greenberg, Aidan R. Vining, and David L.
Weimer. 2018. Cost-Benefit Analysis: Concepts and Practice. 5th
ed. Cambridge, UK: Cambridge University Press.
Bobinac, N., J. van Exel, F. F. H. Rutten, and W. B. F. Brouwer. 2010.
“Willingness to Pay for a Quality-Adjusted Life-Year: The
Individual Perspective.” Value in Health 13 (8):
1046–55.
https://doi.org/10.1111/j.1524-4733.2010.00783.x.
Brealey, Richard A., Stewart C. Myers, Franklin Allen, Simon Benninga,
and Julian Read. 2023. Principles of Corporate Finance. 14th
ed. New York, NY: McGraw-Hill Education.
Cronbach, Lee J. 1951.
“Coefficient Alpha and the Internal
Structure of Tests.” Psychometrika 16 (3): 297–334.
https://doi.org/10.1007/BF02310555.
Devleesschauwer, Brecht, Paul Torgerson, Johannes Charlier, Bruno
Levecke, Nicolas Praet, Sophie Roelandt, Suzanne Smit, Pierre Dorny,
Dirk Berkvens, and Niko Speybroeck. 2022.
Prevalence: Tools for
Prevalence Assessment Studies. https://cran.r-project.org/package=prevalence.
Frederick, Shane, George Loewenstein, and Ted O’Donoghue. 2002.
“Time Discounting and Time Preference: A Critical Review.”
Journal of Economic Literature 40 (2): 351–401.
https://doi.org/10.1257/002205102320161311.
GBD 2019 Demographics Collaborators. 2020.
“Global
Age-Sex-Specific Fertility, Mortality, Healthy Life Expectancy (HALE),
and Population Estimates in 204 Countries and Territories, 1950-2019: A
Comprehensive Demographic Analysis for the Global Burden of Disease
Study 2019.” The Lancet 396 (10258): 1160–1203.
https://doi.org/10.1016/S0140-6736(20)30977-6.
GBD 2019 Risk Factors Collaborators. 2020.
“Global Burden of 87
Risk Factors in 204 Countries and Territories, 1990–2019.”
The Lancet.
https://doi.org/10.1016/S0140-6736(20)30752-2.
Hammitt, James K. 2007.
“Valuing Changes in Mortality Risk: Lives
Saved Versus Life Years Saved.” Review of Environmental
Economics and Policy 1 (2): 228–40.
https://doi.org/10.1093/reep/rem015.
Harvey, Charles M. 1986.
“Value Functions for Infinite-Period
Planning.” Management Science 32 (9): 1123–39.
https://doi.org/10.1287/mnsc.32.9.1123.
Jerrett, Michael, Richard T Burnett, Bernardo S Beckerman, Michelle C
Turner, Daniel Krewski, George Thurston, Randall V Martin, et al. 2013.
“Spatial Analysis of Air Pollution and Mortality in
California.” American Journal of Respiratory and Critical
Care Medicine 188 (5): 593–99.
https://doi.org/10.1164/rccm.201303-0609OC.
Kim, Young-Eun, Yoon-Sun Jung, Minsu Ock, and Seok-Jun Yoon. 2022.
“DALY Estimation Approaches: Understanding and Using the
Incidence-Based Approach and the Prevalence-Based Approach.”
J. Prev. Med. Public Health 55 (1): 10–18.
https://doi.org/10.3961/jpmph.21.597.
Lehtomäki, Heli, Gunn Marit Aasvang, Gerhard Sulo, Bruce R. Denby, Otto
Olavi Hänninen, Michael Brauer, Gavin Pereira, Omid Dadras, and Anette
Kocbach Bølling. 2025.
“Burden of Disease Attributable to
PM2.5 at Low Exposure Levels: Impact of Methodological
Choices.” Environmental Health 25 (1): 4.
https://doi.org/10.1186/s12940-025-01250-y.
Lipman, Stefan A., and Arthur E. Attema. 2024.
“A Systematic
Review of Unique Methods for Measuring Discount Rates.”
Journal of Risk and Uncertainty 69 (2): 145–89.
https://doi.org/10.1007/s11166-024-09439-1.
Mazur, James E. 1987. “An Adjusting Procedure for Studying Delayed
Reinforcement.” In Quantitative Analyses of Behavior: Volume
v. The Effect of Delay and of Intervening Events on Reinforcement
Value, edited by Michael L. Commons, James E. Mazur, John A. Nevin,
and Howard Rachlin, 55–73. Hillsdale, NJ: Lawrence Erlbaum Associates.
Miller, B G, and J F Hurley. 2003.
“Life Table Methods for
Quantitative Impact Assessments in Chronic Mortality.”
Journal of Epidemiology & Community Health 57 (3): 200–206.
https://doi.org/10.1136/jech.57.3.200.
Miller, Brian G. 2010.
“Report on Estimation of Mortality Impacts
of Particulate Air Pollution in London.” Institute of
Occupational Medicine (IOM).
https://cleanair.london/app/uploads/CAL-098-Mayors-health-study-report-June-2010-1.pdf.
Mogin, Gaëlle, Vanessa Gorasso, Jane Idavain, Maria Lepnurm, Sabrina
Delaunay-Havard, Anette Kocbach Bølling, Jurgen Buekers, Axel Luyten,
Brecht Devleesschauwer, and Carl Michael Baravelli. 2025.
“A
Scoping Review of Multiple Deprivation Indices in Europe.”
European Journal of Public Health 35 (6): 1122–28.
https://doi.org/10.1093/eurpub/ckaf190.
Murray, Christopher J L, Majid Ezzati, Alan D Lopez, Anthony Rodgers,
and Stephen Vander Hoorn. 2003. “Comparative Quantification of
Health Risks Conceptual Framework and Methodological Issues.”
Popul. Health Metr. 1 (1): 1.
Murray, Christopher JL, Majid Ezzati, Alan D Lopez, Anthony Rodgers, and
Stephen Vander Hoorn. 2003.
“Comparative Risk Assessment:
Conceptual Framework and Design.” Epidemiology 14 (4):
447–58.
https://doi.org/10.1186/1478-7954-1-1.
OECD. 2025.
Mortality Risk Valuation in Policy Assessment: A Global
Meta-Analysis of Value of Statistical Life Studies. Paris: OECD
Publishing.
https://doi.org/10.1787/76ca89a2-en.
Otavova, Martina, Christel Faes, Catherine Bouland, Eva De Clercq, Bram
Vandeninden, Thierry Eggerickx, Jean-Paul Sanderson, Brecht
Devleesschauwer, and Bruno Masquelier. 2022.
“Inequalities in
Mortality Associated with Housing Conditions in Belgium
Between 1991 and 2020.” BMC Public Health 22 (1): 2397.
https://doi.org/10.1186/s12889-022-14819-w.
Pozzer, A., S. C. Anenberg, S. Dey, A. Haines, J. Lelieveld, and S.
Chowdhury. 2023.
“Mortality Attributable to Ambient Air Pollution:
A Review of Global Estimates.” GeoHealth 7 (1):
e2022GH000711. https://doi.org/
https://doi.org/10.1029/2022GH000711.
Renard, Françoise, Brecht Devleesschauwer, Niko Speybroeck, and Patrick
Deboosere. 2019.
“Monitoring Health Inequalities When the
Socio-Economic Composition Changes: Are the Slope and Relative Indices
of Inequality Appropriate? Results of a Simulation
Study.” BMC Public Health 19 (1): 662.
https://doi.org/10.1186/s12889-019-6980-1.
Robert, Christian P, and George Casella. 2004.
Monte Carlo
Statistical Methods. Springer Texts in Statistics. Springer Science
& Business Media.
https://doi.org/10.1007/978-1-4757-4145-2.
Rubinstein, Reuven Y., and Dirk P. Kroese. 2016.
Simulation and the
Monte Carlo Method. John Wiley & Sons.
https://doi.org/10.1002/9781118631980.
Samuelson, Paul A. 1937.
“A Note on Measurement of
Utility.” The Review of Economic Studies 4 (2): 155–61.
https://doi.org/10.2307/2967612.
Soares, J., A. González Ortiz, A. Gsella, J. Horálek, D. Plass, and S.
Kienzler. 2022.
“Health Risk Assessment of Air Pollution and the
Impact of the New WHO Guidelines (Eionet Report – ETC HE
2022/10).” Eionet Report -- ETC HE 2022/10. European Topic Centre
on Human Health; the Environment.
https://doi.org/10.5281/zenodo.7405988.
Steenland, Kyle, and Ben Armstrong. 2006.
“An Overview of Methods
for Calculating the Burden of Disease Due to Specific Risk
Factors.” Epidemiology 17 (5): 512–19.
https://doi.org/10.1097/01.ede.0000229155.05644.43.
Strak, Maciek, Danny Houthuijs, and Brigit Staatsen. 2024. “D1.2
Report on the Methodology for Assessing the Burden of Correlated
Exposures.” EU Project BEST-COST.
VanderWeele, Tyler J. 2019.
“Optimal Approximate Conversions of
Odds Ratios and Hazard Ratios to Risk Ratios.”
Biometrics 76 (3): 746–52.
https://doi.org/10.1111/biom.13197.
WHO. 2003.
“Introduction and Methods: Assessing the Environmental
Burden of Disease at National and Local Levels.” World Health
Organization.
https://www.who.int/publications/i/item/9241546204.
———. 2011.
“Burden of Disease from Environmental Noise:
Quantification of Healthy Life Years Lost in Europe.” World
Health Organization.
https://www.who.int/publications/i/item/burden-of-disease-from-environmental-noise-quantification-of-healthy-life-years-lost-in-europe.
———. 2020.
“Health Impact Assessment of Air Pollution: AirQ+ Life
Table Manual.” World Health Organization - Regional Office for
Europe.
https://www.who.int/europe/publications/i/item/WHO-EURO-2020-1559-41310-56212.
WHO Regional Office for Europe. 2014.
WHO Expert Meeting: Methods
and Tools for Assessing the Health Risks of Air Pollution at Local,
National and International Level. Meeting Report; 12-13 May 2014; Bonn,
Germany. Copenhagen: WHO Regional Office for Europe.
https://iris.who.int/handle/10665/142940.
Wickham, Hadley. 2014.
“Tidy Data.” Journal of
Statistical Software 59 (10): 1–23.
https://doi.org/10.18637/jss.v059.i10.
———. 2016.
Ggplot2: Elegant Graphics for Data Analysis.
Springer-Verlag New York.
https://ggplot2.tidyverse.org.
Social aspects
Health impact attributable to social indicator
Goal
E.g., to estimate the health impact that is theoretically attributable to the difference in degree of deprivation of the population exposed.
Methodology
Taking into account socio-economic indicators, e.g. a multiple deprivation index (Mogin et al. 2025), the differences in attributable health impacts across the study areas can be estimated (Renard et al. 2019; Otavova et al. 2022).
Social inequalities are quantified as the difference between the least deprived areas (the last n-quantile) and
the most deprived areas or
the population overall.
These differences can be
absolute or
relative.
Difference most deprived vs. least deprived
\[ absolute\_quantile = first - last \] Where:
\[ relative\_quantile = \frac{absolute\_quantile}{last} \]
Difference overall vs. least deprived
\[ absolute\_overall = overall - last \] Where:
If you assume that the least deprived areas are similar to counter-factual cases (no exposure to deprivation), the relative difference regarding the overall average health impact could be interpreted as some kind of relative risk attributable to social inequalities.
Function call
First, quantify health impacts.
Second, use the function
socialize()entering the whole output ofattribute_health()in the argumentoutput_attribute.Alternatively, you can directly enter the health impact in the
socialize()argumentimpact.Main results
Multiple deprivation index
Goal
E.g., to estimate the multiple deprivation index (MDI) to use it for the argument
social_indicatorin the functionsocialize().Methodology
Socio-economic indicators (e.g., education level, employment status and family structure) can be condensed into a multiple deprivation index (MDI) (Mogin et al. 2025). For this purpose, the indicators can be normalized using min-max scaling.
The reliability of the MDI can be assessed using Cronbach’s alpha (Cronbach 1951).
\[ \alpha = \frac{k}{k - 1} \left( 1 - \frac{\sum_{i=1}^{k} \sigma^2_{y_i}}{\sigma^2_x} \right) \] where:
To apply this approach, you should ensure that the data set is as complete as possible. Otherwise, you can try to impute missing data using: - Time-Based Imputation: Linear regression based on historical trends if prior years’ data is complete. - Indicator-Based Imputation: Multiple linear regression if the missing indicator correlates strongly with others.
Imputation models should have an R^2 greater than or equal to 0.7. If R^2 lower than 0.7, consider alternative data sources or methods.
Function call
Note:
verbose = FALSEsuppresses any output to the console (default:verbose = TRUE, i.e. with printing turned on).Main results
Function output includes:
mdi_main, a tibble containing the BEST-COST MDIThe function assesses the reliability of the MDI based on the Cronbach’s alpha value as follows: - 0.9 and higher: Excellent reliability - between 0.8 (included) and 0.9: Good reliability - between 0.7 (included) and 0.8: Acceptable reliability - between 0.6 (included) and 0.7: Questionable reliability - lower than 0.6: Poor reliability
Detailed results
mdi_detailedDESCRIPTIVE STATISTICS
PEARSON’S CORRELATION COEFFICIENTS
CRONBACH’S α, including the reliability rating this value indicates
Code for boxplots of the single indicators
Code for histogram of the MDI’s for the geo units with a normal distribution curve
To reproduce the boxlots run