invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline
A set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including – but not limited to – chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.
| Version: | 0.0.13 |
| Depends: | R (≥ 3.5.0) |
| Imports: | runjags, parallel, readxl, coda, ggplot2, scales, stats4, Rdpack, methods, stats, utils, dplyr, rlang |
| Suggests: | knitr, R.rsp, tidyverse, gridExtra, gridtext, flextable, rmarkdown, magrittr, stringr |
| Published: | 2025-08-19 |
| DOI: | 10.32614/CRAN.package.invitroTKstats |
| Author: | John Wambaugh 
[aut],
Sarah E. Davidson-Fritz
[aut, cre],
Lindsay Knupp [ctb],
Barbara A. Wetmore
[ctb],
Zhao Zhihui [ctb],
Chantel Nicolas
[ctb],
Anna Kreutz [ctb],
U.S. Federal Government [cph] (Copyright holder of this package) |
| Maintainer: | Sarah E. Davidson-Fritz <davidsonfritz.sarah at epa.gov> |
| BugReports: | https://github.com/USEPA/invitroTKstats/issues |
| License: | MIT + file LICENSE |
| URL: | https://github.com/USEPA/invitroTKstats |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| CRAN checks: | invitroTKstats results |
Documentation:
| Reference manual: | invitroTKstats.html , invitroTKstats.pdf |
| Vignettes: |
Appendix (source, R code) Caco-2 (source, R code) Clint (source, R code) data_guide_and_LO (source, R code) Fup RED (source, R code) Fup UC (source, R code) Plotting Functions (source, R code) |
Downloads:
| Package source: | invitroTKstats_0.0.13.tar.gz |
| Windows binaries: | r-devel: invitroTKstats_0.0.13.zip, r-release: invitroTKstats_0.0.13.zip, r-oldrel: invitroTKstats_0.0.13.zip |
| macOS binaries: | r-release (arm64): invitroTKstats_0.0.13.tgz, r-oldrel (arm64): invitroTKstats_0.0.13.tgz, r-release (x86_64): invitroTKstats_0.0.13.tgz, r-oldrel (x86_64): invitroTKstats_0.0.13.tgz |
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