OptOR: Optimal Hyperrectangular Operating Regions

Computes optimal axis-aligned hyperrectangles for discrete binary arrays and continuous regions defined by quadratic response functions. The package provides methods for discrete optimization, grid classification, continuous refinement, and exact global extrema calculations. Applications include the identification of practical operating regions within multivariate design spaces, including pharmaceutical development settings related to ICH Q8.

Version: 0.1.0
Imports: stats
Suggests: ggplot2, grid, knitr, rmarkdown, testthat (≥ 3.0.0)
Published: 2026-09-12
DOI: 10.32614/CRAN.package.OptOR
Author: Christian Palmes [aut, cre], Bayer AG [cph], Raluca Ilinca Schmitt [ctb], Adrian Funke [ctb]
Maintainer: Christian Palmes <christian.palmes at bayer.com>
License: MIT + file LICENSE
NeedsCompilation: yes
Language: en-US
CRAN checks: OptOR results

Documentation:

Reference manual: OptOR.html , OptOR.pdf
Vignettes: Getting Started with OptOR (source, R code)

Downloads:

Package source: OptOR_0.1.0.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): OptOR_0.1.0.tgz, r-release (x86_64): OptOR_0.1.0.tgz, r-oldrel (x86_64): OptOR_0.1.0.tgz

Linking:

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