| Table 10 (replicated) |
| Metric |
Base scenario |
Lower CL |
| Cmax (geomean) |
|
|
| 5% Centile |
30.75 |
43.56 |
| Median |
31.13 |
44.35 |
| 95% Centile |
31.83 |
45.12 |
| Cmax (geocv) |
|
|
| 5% Centile |
17.06 |
15.74 |
| Median |
18.97 |
17.96 |
| 95% Centile |
20.18 |
19.03 |
| AUC (geomean) |
|
|
| 5% Centile |
321.8 |
635.1 |
| Median |
330.4 |
651.7 |
| 95% Centile |
337.4 |
664.6 |
| AUC (geocv) |
|
|
| 5% Centile |
21.22 |
20.01 |
| Median |
23.51 |
22.40 |
| 95% Centile |
23.87 |
22.86 |
| AUC > 300 (n_TRUE) |
|
|
| 5% Centile |
63.00 |
100.0 |
| Median |
66.00 |
100.0 |
| 95% Centile |
75.00 |
100.0 |
| AUC > 300 (N_TRUE) |
|
|
| 5% Centile |
100.0 |
100.0 |
| Median |
100.0 |
100.0 |
| 95% Centile |
100.0 |
100.0 |
| AUC > 300 (p_TRUE) |
|
|
| 5% Centile |
0.6300 |
1.000 |
| Median |
0.6600 |
1.000 |
| 95% Centile |
0.7500 |
1.000 |