| Metric | Base scenario N = 241 |
Lower clearance N = 241 |
|---|---|---|
| Last dose in '1g QD' arm | ||
| AUC (ng/mL*h) | 305 (230–543) | 457 (344–805) |
| Cmax (ng/mL) | 31 (23–53) | 37 (28–64) |
| Cmax > 30 (%) | 15 / 24 (63%) | 21 / 24 (88%) |
| tmax (h) | 0.80 (0.50–1.70) | 0.80 (0.50–1.90) |
| Ctrough (ng/mL) | 5.1 (3.1–13.2) | 10.4 (7.0–23.5) |
| t½ (h) | 14.2 (12.9–19.9) | 15.9 (12.5–28.5) |
| Last dose in '0.5 BID' arm | ||
| AUC (ng/mL*h) | 169 (127–234) | 253 (191–346) |
| Cmax (ng/mL) | 20.7 (15.8–24.7) | 27.7 (21.5–34.0) |
| Cmax > 30 (%) | 0 / 24 (0%) | 6 / 24 (25%) |
| tmax (h) | 0.80 (0.60–1.20) | 0.85 (0.70–1.30) |
| Ctrough (ng/mL) | 9.7 (6.8–15.2) | 16.5 (11.9–24.6) |
| t½ (h) | 13.4 (12.1–18.2) | 17.9 (12.0–26.7) |
| 1 Median (5% Centile–95% Centile); n / N (%) | ||