| Metric | 1g QD N = 241 |
0.5g BID N = 241 |
|---|---|---|
| Base scenario | ||
| AUC (ng/mL*h) | 305 (230–543) | 338 (254–467) |
| Cmax (ng/mL) | 31 (23–53) | 21 (16–25) |
| Cmax > 30 (%) | 15 / 24 (63%) | 0 / 24 (0%) |
| tmax (h) | 0.80 (0.50–1.70) | 12.80 (12.60–13.20) |
| Ctrough (ng/mL) | 5.1 (3.1–13.2) | 9.7 (6.8–15.2) |
| t½ (h) | 14.24 (12.89–19.87) | 13.44 (12.10–18.15) |
| Lower clearance | ||
| AUC (ng/mL*h) | 457 (344–805) | 506 (381–691) |
| Cmax (ng/mL) | 37 (28–64) | 28 (22–34) |
| Cmax > 30 (%) | 21 / 24 (88%) | 6 / 24 (25%) |
| tmax (h) | 0.80 (0.50–1.90) | 12.85 (12.70–13.30) |
| Ctrough (ng/mL) | 10.4 (7.0–23.5) | 16.5 (11.9–24.6) |
| t½ (h) | 15.9 (12.5–28.5) | 17.9 (12.0–26.7) |
| 1 Median (5% Centile–95% Centile); n / N (%) | ||